2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137324
    α-Apooxytetracycline
    α-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is an antibiotic belonging to the tetracycline class.
    α-Apooxytetracycline
  • HY-W662579
    N-Desmethyl clotiazepam
    N-Desmethyl clotiazepam (Desmethylclotiazepam) is an active metabolite of Clotiazepam.
    N-Desmethyl clotiazepam
  • HY-122489R
    DL-Laudanosine (Standard)
    DL-Laudanosine (Standard) is the analytical standard of DL-Laudanosine. This product is intended for research and analytical applications. DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood–brain barrier and may cause excitement and seizure activity.
    DL-Laudanosine (Standard)
  • HY-B1786R
    Sulindac sulfide (Standard)
    Sulindac sulfide (Standard) is the analytical standard of Sulindac sulfide. This product is intended for research and analytical applications. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.
    Sulindac sulfide (Standard)
  • HY-16445BR
    CNDAC (hydrochloride) (Standard)
    Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity.
    CNDAC (hydrochloride) (Standard)
  • HY-N10508
    Calcitroic acid
    Calcitroic acid is a vitamin D receptor (VDR) agonist that can activate VDR-mediated transcription. Calcitroic acid is the main metabolite of 1,25-dihydroxyvitamin D3, with the highest concentrations found in the liver and mucosa of mice, and it has metabolic stability and very low toxicity.
    Calcitroic acid
  • HY-W704772
    S-Methyl-D-penicillamine
    		Control
    S-Methyl-D-penicillamine is a metabolite of the chelating agent Penicillamine (HY-B0300).
    S-Methyl-D-penicillamine
  • HY-133728
    Piribedil N-oxide
    Piribedil N-oxide is a metabolite of the dopamine receptor agonist Piribedil (HY-12707).
    Piribedil N-oxide
  • HY-W505108
    2,3-Dihydroxypropyl pentadecanoate
    2,3-Dihydroxypropyl pentadecanoate is a monoacylglycerol that is found in wheat bran extracts. 2,3-Dihydroxypropyl pentadecanoate levels are increased in a HepaRG cell-based model of hepatic steatosis induced by BSA-conjugated palmitate.
    2,3-Dihydroxypropyl pentadecanoate
  • HY-W278566R
    Saluamine (Standard)
    Saluamine (Standard) is the analytical standard of Saluamine. This product is intended for research and analytical applications. Saluamine is a metabolite of Furosemide (HY-B0135).
    Saluamine (Standard)
  • HY-W587485
    N-acetyl-S-(trichlorovinyl)-L-cysteine
    N-acetyl-S-(trichlorovinyl)-L-cysteine is a metabolite of the volatile organic compound (VOC).
    N-acetyl-S-(trichlorovinyl)-L-cysteine
  • HY-Z7660
    Lansoprazole N-oxide
    Lansoprazole N-oxide (Comound 2) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole N-oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome.
    Lansoprazole N-oxide
  • HY-W750822
    7-APB hydrochloride
    		Control
    7-APB hydrochloride is a benzofuran. 7-APB hydrochloride is a metabolite of 7-MAPB.
    7-APB hydrochloride
  • HY-W588247
    S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine
    S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SF-cysteine), a metabolite of Sulforaphane (HY-13755), can enhance the survival rate of Nalm-6 cells.
    S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine
  • HY-N11224
    Pregnanetriol
    Pregnanetriol is a metabolite of 17α-Hydroxyprogesterone (HY-B0891). 17α-Hydroxyprogesterone is an endogenous progesterone.
    Pregnanetriol
  • HY-129718
    Nafimidone alcohol
    Nafimidone alcohol is the major metabolic of Nafimidone in plasma and urine. Nafimidone alcohol is promising for research of onset seizures.
    Nafimidone alcohol
  • HY-134670R
    a-Hydroxymetoprolol (Standard)
    a-Hydroxymetoprolol (Standard) is the analytical standard of a-Hydroxymetoprolol. This product is intended for research and analytical applications. a-Hydroxymetoprolol is a metabolite of metoprolol. The adrenoreceptor blocking effect of a-Hydroxymetoprolol on metoprolol is almost zero.
    a-Hydroxymetoprolol (Standard)
  • HY-127159
    Laurencin
    		Inhibitor
    Laurencin is a cyclic ether, which can be isolated red alga L. glandulifera. Laurencin prolongs the pentobarbitone-induced sleep time through inhibition of pentobarbitone metabolism.
    Laurencin
  • HY-W681822
    (R,S,S)-Dihydrotetrabenazine
    (R,S,S)-Dihydrotetrabenazine (R,S,S-DHTBZ) is a kind of discrete isomeric secondary alcohol metabolites of Tetrabenazine (TBZ, HY-B0590), is a poor VMAT2 inhibitor (Ki = 690 nM).
    (R,S,S)-Dihydrotetrabenazine
  • HY-W072459
    6'-Hydroxydihydrocinchonidine
    6'-Hydroxydihydrocinchonidine is a metabolite of Quinine (HY-D0143) (antimalarial agent).
    6'-Hydroxydihydrocinchonidine
Cat. No. Product Name / Synonyms Application Reactivity